• The hepatic cytochrome P CYP superfamily is

  2020-11-30

  

  The hepatic cytochrome P450 (CYP450) superfamily is essential for metabolising foreign chemicals, fatty acids, vitamins, hormones and other compounds and consists of 18 subfamilies (Uno et al., 2012). The number of discovered CYP genes is increasing as a result of intense work with CYP450 gene struc

• br Discussion Nowadays data of

  2020-11-30

  

  Discussion Nowadays, data of uncommon EGFR mutations are limited, considering that patients carrying these rare alterations are usually excluded from clinical trials. Available survival data of activity of EGFR TKIs on this class of mutations, coming from a small number of usually retrospective s

• br Conclusions Mulan is a mitochondrial E ubiquitin

  2020-11-28

  

  Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy. To better understand the mechanism of Mulan's function we used a modified yeast two-hybrid system to isolate proteins that interact with its cytoplasmic RING domain (amino acids

• All known vertebrate TRIMs are categorized in

  2020-11-28

  

  All known vertebrate TRIMs are categorized in 11 distinct subclasses depending on the types of domains present at their carboxyl-terminals (Fig. 3) [29], [35]. Beyond conserved N-terminal domains, it is the C-terminal that provides specificity of interactions with other proteins. The subclass IV for

• br Conclusion In the last year

  2020-11-28

  

  Conclusion In the last year, significant advances in our understanding of ubiquitin transfer by IAPs and related E3 ligases have been made. The three crystal structures of the RING-bound E2~Ub show that the conjugate is bound by the RING domain in the closed conformation, where the I44-centered f

• br Compliance with ethical standards

  2020-11-28

  

  Compliance with ethical standards This work was conducted in compliance with ethical standards. Conflict of interest Funding The work was funded by extra mural research grant (EMR/2016/005135) from Science and Engineering Research Board, Government of India. Acknowledgements Introduc

• br Experimental section br Author contributions br Acknowled

  2020-11-28

  

  Experimental section Author contributions Acknowledgements Introduction Many ibotenic acid sale in cells are sequential enzymatic reactions where the product of one enzyme serves as the substrate of a second enzyme (1, 2). Experimental evidence suggests that some of these consecutive en

• Classical DHFR inhibitors such as methotrexate MTX bind tigh

  2020-11-28

  

  Classical DHFR inhibitors such as methotrexate (MTX) bind tightly to the enzyme and possess adequate clinical pharmacokinetics. MTX bind to the DHFR binding site through the formation of hydrogen bonds with Asn64, Lys68, Arg28, Arg70, Val115 and Ile7 amino hcv protease inhibitors residues as well a

• br Introduction Acylglycerol acyltransferases AGATs are pred

  2020-11-28

  

  Introduction Acylglycerol acyltransferases (AGATs) are predominantly responsible for triglyceride synthesis in the body, via two major pathways: the glycerol phosphate (GP) pathway (Kennedy, 1957) and the monoacylglycerol (MG) pathway (see Coleman and Lee, 2004, Yen et al., 2008). The final step

• The fibrillogenesis process of collagen

  2020-11-28

  

  The fibrillogenesis process of collagen is understood to initiate in the extracellular space near the plasma membrane where secretory vesicles form regions of deep invagination. However, it is not clear how and when collagen-binding proteins interact with collagen molecules during fibrillogenesis or

• The first transcription factor TF known

  2020-11-28

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone aldehyde dehydrogenase inhibitor of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions

• Natural and synthetic glucocorticoids perform their biologic

  2020-11-28

  

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.

• The excitatory amino acid L glutamate or glutamate mediates

  2020-11-28

  

  The excitatory amino glycogen phosphorylase L-glutamate or glutamate mediates most of the excitatory neurotransmission within the mammalian central nervous system (CNS) and has been implicated in numerous peripheral nervous system (PNS) pathways. The excitatory amino acids, including glutamate, are

• The mutation in Caucasian people of European

  2020-11-28

  

  The Δ32 mutation in Caucasian people of European heritage is quite common but extremely rare in Asian and African countries (Huang et al., 1996). We recently reported the presence of this mutation from India (Husain et al., 1998a) and established the complete inheritance pattern (Husain et al., 1998

• Beside the previously reported Topo

  2020-11-28

  

  Beside the previously reported Topo I inhibition, time and concentration dependent CRM1 inhibitory properties of klavuzon derivatives have been shown as a second mechanism of action in this work. Especially, compounds 3 and 20 are the most effective derivatives and they completely inhibit CRM1 activ

16334 records 769/1089 page Previous Next First page 上5页 766767768769770 下5页 Last page