• Although it is well established that

  2021-08-24

  

  Although it is well established that estrogen and ESR1 mediate numerous reproductive processes, increasing evidence suggests that ESR2 also lays an integral role in reproduction. ESR2 is a mediator in folliculogenesis and may also act by stimulating ovulation and regulating luteinization (Su et al.,

• Increased leukocyte trafficking and infiltration of

  2021-08-24

  

  Increased leukocyte trafficking and infiltration of the vascular wall are thought to provide a key stimulus for SMC activation and subsequent neointima formation in response to vascular injury [19], [20]. The essential trigger regulating the accumulation of leukocytes in the vessel wall is the upreg

• br Materials and methods br Results br Discussion PKA and

  2021-08-24

  

  Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig

• The compounds listed in Table Table

  2021-08-24

  

  The compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5 were biologically evaluated for their inhibition of the specific binding of a radiolabeled ligand [3H]PGE2 to membrane fractions prepared from cells stably expressing each mouse prostanoid receptor. The EP1 antagonist activity of th

• lysophospholipid receptor br Introduction Epithelial mesench

  2021-08-24

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial lysophospholipid receptor lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation d

• MI has been detected in

  2021-08-24

  

  3MI has been detected in wastewater at concentrations of 640–700 μg L−1 (Hwang et al., 1995) and up to 20 mg L−1 in decaying algal water environments (Peller et al., 2014). It is likely that 3MI accumulation in fish might be due to the degradation of endogenous amino acids. The presence of this che

• Our study found a significant association between

  2021-08-24

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P EGFR endothelin receptor status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between

• Interestingly our analyses of human PBMCs using a

  2021-08-24

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 Hydroxysafflor yellow A showed homogeneous high expression of EBI2 compared with Th1 cells, which contained

• br Experimental Procedures Further details and

  2021-08-24

  

  Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific Berberine hydrochloride migrate to the periphery of B cell folli

• MK-0457 Similarly synthetic analogs of Alogliptin

  2021-08-24

  

  Similarly synthetic analogs of Alogliptin by replacing the cyanobenzyl group with the butynyl group have been synthesized and tested as selective DPP-4 inhibitors [7], [8]. Additionally, quinazolines [9], [10], pyridopyrimidinediones [11], pyrazolopyrimidinones [12] and pyrimidines [13] as DPP-IV in

• Importantly in genetic studies Saccharomyces cerevisiae Pif

  2021-08-24

  

  Importantly, in genetic studies, Saccharomyces cerevisiae Pif1, a member of the SF1 family of helicases, has been implicated in BIR in conjunction with Pol δ (Chung et al., 2010, Saini et al., 2013, Wilson et al., 2013). Using highly purified S. cerevisiae proteins, a system that permits dissection

• Introduction Trichloroacetic acid TCA might enhance the acti

  2021-08-24

  

  Introduction Trichloroacetic AI-10-49 receptor (TCA) might enhance the activation of T cells and disrupt various activities of peripheral T cells [1], which is related to human immune function and reduces human immunity. Trichloroethylene (TCE) has been widely used in many manufacturing industries

• Voriconazole receptor br Material and methods br Results br

  2021-08-24

  

  Material and methods Results Discussion Ligase IV is essential for the final ligation of DSBs through the NHEJ pathway. Its co-factor, XRCC4, has been shown to be important for increasing its activity and stability. Interaction between these two factors have been mapped to the linker region

• Currently it is not known if drought induces

  2021-08-23

  

  Currently, it is not known if drought induces changes in the cysteine protease salubrinal of soybean nodules. The available annotation of the soybean genome, in Phytozome (www.phytozome.net) has identified 706 C1 cysteine protease sequences and 75 C13 cysteine proteases. We have previously reported

• First we synthesized inhibitor following the

  2021-08-23

  

  First, we synthesized inhibitor following the patent procedure reported by Shewchuk et al. to provide its first complete characterization (see ). Two different synthetic approaches were used to obtain compounds –. The first method relied on the alkylation of the common 5-phenol-2,4-diaminopyrimidin

16510 records 620/1101 page Previous Next First page 上5页 616617618619620 下5页 Last page