• In addition at the spinal level results from colocalization

  2022-01-20

  

  In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou

• thousands of Isoflurane administration during i t procedure

  2022-01-20

  

  Isoflurane administration during i.t. procedures can complicate the interpretation of our results since isoflurane has been shown to have both neuroprotective and neurotoxic effects (Jiang et al., 2017). Isoflurane pretreatment has been implicated as having protective effects in ischemia in animal m

• Activation of FXR or TGR inhibits inflammatory response

  2022-01-20

  

  Activation of FXR or TGR5 inhibits inflammatory response via repressing NF-κB activity [1]. FXR is not expressed or expressed at a very low level in macrophages [45] (data not shown), but highly expressed in hepatocytes. In contrast, TGR5 is expressed in macrophages but not in hepatocytes. Our data

• A mutation in stearoyl coenzyme A

  2022-01-20

  

  A mutation in stearoyl coenzyme A desaturase 1 gene was reported to reduce sebum production and monounsaturated fatty acids (MUFA) synthesis in mice, which was accompanied with impaired clearance of gram-positive bacteria-induced skin infection (Georgel et al., 2005). Interestingly, gram-positive ba

• br Acknowledgements This study was supported

  2022-01-20

  

  Acknowledgements This study was supported by National Institutes of Health grant (R01GM104037), VA grant (BX002741), and Rutgers Busch grant. Nuclear receptor FXR is the master regulator of bile acids homeostasis The farnesoid X receptor (FXR) belongs to a family of proteins known as nuclear

• Growing evidence supporting the anti inflammatory

  2022-01-20

  

  Growing evidence supporting the anti-inflammatory and tissue-protective effects of FPR antagonists led to the screening of commercial libraries for novel small-molecule FPR antagonists. As result of these screening efforts and/or structure–activity relationship (SAR)-directed design and synthesis, a

• glucagon receptor So what makes a FFAR agonist

  2022-01-20

  

  So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept

• br RESULTS br DISCUSSION In this study we found impaired

  2022-01-20

  

  RESULTS DISCUSSION In this study, we found impaired apoptosis in the peripheral blood of RA patients when compared with peripheral blood from normal controls. Our previous studies have shown that the number of CD4 + T LY2090314 increased while regulatory T (Treg) cells diminished in the perip

• During the activation of the coagulation cascade factor

  2022-01-20

  

  During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium nucleoside analog on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhi

• A 967079 australia br Materials and methods br Results

  2022-01-20

  

  Materials and methods Results Discussion Several histamine H3 receptor antagonists have progressed into clinical development for indications including Alzheimer's disease, schizophrenia, pain and narcolepsy. Each of the compounds studied herein has been extensively characterized in its own

• An azabicyclic compound named S a a hexahydro

  2022-01-20

  

  An azabicyclic abk named S 38093, (4-[3-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)propoxy]benzamide), was introduced by Servier with H3R antagonist and inverse agonist activity (Sors et al., 2017). The compound contains all the drug-likeness criteria owing to its physicochemical propertie

• In mammalian cells Motins have been identified as

  2022-01-20

  

  In mammalian cells, Motins have been identified as a key link between F-actin and Hippo pathway regulation, as knockdown of all three Motins increased Yap activity even in the presence of cytoskeletal disruption [105]. Motins can physically associate with F-actin but this association is blocked by p

• br Hippo Signaling in Autoimmunity An imbalance

  2022-01-20

  

  Hippo Signaling in Autoimmunity An imbalance of T cell subsets, such as immunosuppressive regulatory T GX15-070 (Treg) and inflammatory TH17, has a key role in autoimmune diseases. Recently, investigations found that TAZ but not YAP enhances TH17 differentiation but attenuates Treg differentiati

• FoxM a downstream target of

  2022-01-20

  

  FoxM1, a downstream target of Gli, has been mainly related to 22 9 regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression (Wonsey & Folletti

• In this study we also

  2022-01-19

  

  In this study, we also investigated the role of GST Tideglusib mg in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a pre

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