• br Concluding remarks br Conflict of

  2022-02-08

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

• br GPR a G protein coupled

  2022-02-08

  

  GPR35, a G protein-coupled receptor (GPCR), was discovered and classified as an orphan GPCR in 1998 and deorphanized in 2006 by the discovery of kynurenic VX-702 as the endogenous agonist. Since its discovery, limited references on the GPR35 receptor have appeared, due in part to a scarcity of end

• br Acknowledgments This publication was supported by NORAD N

  2022-02-07

  

  Acknowledgments This publication was supported by NORAD (Norwegian Agency for Development Cooperation) under the NORHED-Program, agreement no. ETH-13/0024. MCM works at the MRC Integrative Epidemiology Unit which receives infrastructure funding from the UK Medical Research Council (MRC) (MC_UU_12

• br Animal models of NASH The human

  2022-02-07

  

  Animal models of NASH The human NAS system (see above) is largely reproducible in NAFLD mouse models [37] and, therefore, has been increasingly applied in the preclinical assessment of liver histological responses to test compounds. In general, the NAS system is well suited for this purpose, alth

• Obestatin synthetized mainly in the

  2022-02-07

  

  Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra

• Two pathways have emerged to explain the beneficial

  2022-02-07

  

  Two pathways have emerged to explain the beneficial metabolic effect of Roux-en-Y bypass [Fig. 3]. Firstly, the rapid delivery of nutrients to the distal small intestine and bowel might up-regulate secretion of a physiological stimulus that improves glucose homeostasis. As such, GLP-1 represents an

• Puromycin aminonucleoside mg So far several methods have bee

  2022-02-07

  

  So far, several methods have been used to monitor the level of GJC and its regulation in astrocytes studied in acute Puromycin aminonucleoside mg slices (see Giaume et al., 2012). This mainly includes approaches based either on electrophysiological properties of gap junction channels or on “dye cou

• Notwithstanding the functioning of galaninergic system may b

  2022-02-07

  

  Notwithstanding, the functioning of galaninergic system may be even more complex (Fuxe et al., 2012). Some studies present evidence that GAL2 receptors might form heteroreceptor complexes with neuropeptide Y1 receptors in TBB of amygdala (Narváez et al., 2015a), DRN (Díaz-Cabiale et al., 2011) and

• The intestinal epithelium is the first line of defense again

  2022-02-07

  

  The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and Fosinopril sodium of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginations kno

• Biological evaluations of the compounds were done both using

  2022-02-05

  

  Biological evaluations of the compounds were done both using HCV protease and replicon assays. Results are shown in . The protease inhibitory IC’s were determined using a FRET assay with HCV NS3/4A 1a protease domain. The replicon EC’s were determined using a replicon luciferase cell-based assay. Th

• IL had marked effects on the

  2022-02-05

  

  IL-33 had marked effects on the inflammatory response in human adipocytes beyond GPR84, with a substantial stimulation of the expression of a selected group of cytokine and chemokine genes. Expression of IL1B, a co-member of the IL-1 superfamily, was strongly up-regulated by IL-33, as was IL6 and CX

• In conclusion this is the first description of

  2022-02-05

  

  In conclusion, this is the first description of a GPR81 agonist with an ability to exert in vivo efficacy without causing flushing. These results demonstrate that GPR81 small-molecule agonists may be effective for treating dyslipidemia. In addition, targeting GPR81 could prevent the unwanted side ef

• In women with stage I II endometriosis no

  2022-02-04

  

  In women with stage I–II endometriosis [17], no difference in the implantation rate per embryo or in the clinical pregnancy rate per transfer was noted between GnRH-agonist and GnRH-antagonist protocol (18.2% vs. 15.4%, P=0.9 and 31.2% vs. 30%, P=1, respectively). It has been suggested that either

• The association between mental disorders and smoking was

  2022-02-04

  

  The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi

• Introduction Type diabetes T D has been seriously affecting

  2022-02-03

  

  Introduction Type 2 diabetes (T2D) has been seriously affecting the health life of 415 million people and 193 million undiagnosed people [1]. Importantly, this disease was found to cause death at least 1.5 million annually, and has brought about an extensive health concern throughout the world [2,3

16430 records 513/1096 page Previous Next First page 上5页 511512513514515 下5页 Last page