• Targeting the BCR is the ideal strategy to

  2024-06-04

  

  Targeting the BCR is the ideal strategy to identify the antigen reactive B cells. However, there is concern that B cells could be activated when BCR are bound and cross-linked by antigens, a possibility that is obviously negative for the treatment of autoimmune disease. Proby et al. (2000) tried to

• Both subcutaneous s c and mucosal

  2024-06-04

  

  Both subcutaneous (s.c.) and mucosal administration of short synthetic peptide derivatives of AChR prevent the onset of EAMG, but do not treat ongoing EAMG [80], [81], [82], [83], [84], [85]. The selection of peptides for treatment is mainly based on the identification of immunodominant T- and B-cel

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-06-04

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic egfr inhibitors receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis of MG

• Toxicity is the main reason for the failure at

  2024-06-04

  

  Toxicity is the main reason for the failure at all stages of the new drug development process. The major part of safety-related attrition occurs at preclinical phases while predicting preclinical safety liabilities earlier in the drug development process. This strategy enables the design and/or sele

• Matthew et al synthesized and carried out

  2024-06-04

  

  Matthew et al. synthesized and carried out SAR studies of imidazo-[1,2-a]-pyrazine as Aurora kinase inhibitors with enhanced kinase selectivity and found that cytochrome p450 inhibitors 39 showed optimal potency on Aurora-A and Aurora-B with IC50 value of 4 nM and 13 nM while on phosphorylation hist

• Aurora A the polar kinase is

  2024-06-04

  

  Aurora A the ’polar kinase’ is located at the centrosome and is required for its maturation, division, for the mitotic spindle assembly and entry into mitosis., Mutation or transcriptional silencing of Aurora A impairs centrosome maturation and separation, leads to mono/multipolar spindles, to delay

• The evidence points toward a role for LO activity in

  2024-06-04

  

  The evidence points toward a role for 12/15-LO activity in WAT in modulating chronic local inflammation and subsequent systemic metabolic decline in the obese state. However, little is known as to the role of 12- and 15-LOs in BAT. Indeed, in addition to WAT, platelet- and leukocyte-type 12-LO are e

• The evidence points toward a role for LO activity in

  2024-06-04

  

  The evidence points toward a role for 12/15-LO activity in WAT in modulating chronic local inflammation and subsequent systemic metabolic decline in the obese state. However, little is known as to the role of 12- and 15-LOs in BAT. Indeed, in addition to WAT, platelet- and leukocyte-type 12-LO are e

• To enhance the accuracy of SEs in

  2024-06-04

  

  To enhance the accuracy of SEs in eliminating cancer cells, the mAb recognized by specific GDC-0449 on tumor cells were fused with SEs. Fab C215 or C242 fused with SEA promoted apoptosis in human colon carcinoma cells via Fas (Dohlsten et al., 1994, Litton et al., 1996). SEB-incorporated exosomes w

• Gene regulation of MMPs is influenced by

  2024-06-04

  

  Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have custom mrna synthesis in the promoter region of MMPs, as well as in genes mediating inflammatory respon

• We further conducted stratified analyses to observe

  2024-06-04

  

  We further conducted stratified analyses to observe changes in enzyme levels across the periods by subgroups. Fig. 1 shows the changes in GPx levels by subgroups of age, sex, and smoking status. In all participants, GPx levels decreased when air pollution levels declined but increased after the Olym

• br Conflicts of interest br Contributors br Introduction

  2024-06-04

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• Using this cheese mimicking matrix we screened the antifunga

  2024-06-04

  

  Using this cheese-mimicking matrix, we screened the antifungal activity of 44 LAB fermented milk-based products and 23 LAB isolates used as protective cultures against 4 fungal targets. The LAB were obtained from the culture collections of CIRM-BIA (Centre International de Ressources Microbienne-Bac

• br HIF Signaling in AA Therapy

  2024-06-04

  

  HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re

• br Nanoparticle Conjugated Topoisomerase Inhibitors The safe

  2024-06-04

  

  Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5

15676 records 89/1046 page Previous Next First page 上5页 8687888990 下5页 Last page