• br Transparency document br Introduction G protein coupled r

  2023-07-13

  

  Transparency document Introduction G protein-coupled receptors (GPCRs) comprise a diverse family of seven transmembrane domain-containing receptors represented by over 800 genes in humans. GPCRs respond to a range of stimuli, including peptides, hormones, growth factors, lipids, odorants, and

• Active SI behavior was dose dependently affected

  2023-07-13

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p LGX818 1 week later (F3,20 = 8.93, p These results are consistent with our hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.

• To our knowledge BAY has not

  2023-07-13

  

  To our knowledge, BAY 60-6583 has not progressed to clinical development and remains to be the only ADORA2B agonist that has been developed.33, 34 Further development of similar compounds would be beneficial in future fibrosis research. One of the limitations of our study is being limited to in vit

• PC is considered as a cancer of the

  2023-07-12

  

  PC is considered as a cancer of the epigenome (Grasso et al., 2012, Robinson et al., 2015). Our results demonstrate that the interaction of AR with ACK1 drives the positive feedback epigenetic circuitry that is ultimately conducive to promote AR transcription. Further, this circuitry subjugates AR t

• br Acknowledgements br Introduction Autoantibodies

  2023-07-12

  

  Acknowledgements Introduction Autoantibodies directed at neurotransmitter receptors and ion channels are pathogenic and/or biomarkers in several autoimmune neurological diseases [1]. For example, autoantibodies directed against voltage-gated potassium channels, the P/Q-type (α1A) voltage-gated

• Recently biosensors based on enzyme

  2023-07-12

  

  Recently, biosensors based on enzyme-mimicking organic-inorganic hybrid nanomaterials such as protein or DNA-Cu nanoflowers (Batule et al., 2015, Park et al., 2017), Fe-aminoclay (Lee et al., 2013), and MOFs (Ai et al., 2013, Dong et al., 2015, Feng et al., 2012, Liu et al., 2013, Qin et al., 2013,

• Considering the physicochemical stability results on Fig it

  2023-07-12

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• NSAIDs induce gastrointestinal toxicity and evoke asthma by

  2023-07-12

  

  NSAIDs induce gastrointestinal toxicity and evoke nicotinic receptor agonist by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle a

• The following are the supplementary data related to this

  2023-07-12

  

  The following are the supplementary data related to this article. Funding Work in Dr. Rosell's laboratory is partially supported by a grant from La Caixa Foundation, and an Instituto de Salud Carlos III grant (RESPONSE, PIE16/00011). Work in Dr. Cao's laboratory is partially supported by the Maj

• Physiological total plasma LPA levels

  2023-07-12

  

  Physiological total plasma LPA levels are normally less than 1μM in healthy subjects. LPA levels have been reported to be increased in malignant effusions or plasma in cancer patients [20]. In addition, increasing ATX activity detected in healthy pregnant women in the third trimester of pregnancy ex

• In addition to the data provided by the Ki

  2023-07-12

  

  In addition to the data provided by the Ki16425 treatment in the K/BxN arthritis model, new findings from the study of two new LPA receptor antagonists confirm the involvement of the LPA pathway in the pathogenesis of experimental arthritis. In the study by Miyabe et al., the authors reported the t

• In this study we found that

  2023-07-12

  

  In this study, we found that ACL silencing is sufficient to impair myoblast differentiation and that this effect is accompanied by a decrease in MYOD early in the myogenic process and by a subsequent decline in fast MyHC protein caffeic acid phenethyl ester at a later stage of differentiation (Figu

• Secondly leptin has been shown to enhance aromatase mRNA

  2023-07-12

  

  Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer Sitagliptin phosphate monohydrate by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific D

• Regardless of the initial treatment

  2023-07-12

  

  Regardless of the initial treatment, most patients with advanced NSCLC experience relapse and disease progression [15]. A subpopulation of immediate concern and clinical need is patients who have advanced NSCLC that is especially aggressive, which is usually defined as disease that rapidly progresse

• br Concluding Remarks Despite major advances

  2023-07-12

  

  Concluding Remarks Despite major advances in the development of antibody and small-molecule tumor angiogenesis inhibitors, therapy resistance, both innate and acquired, continues to limit further survival improvements for patients with cancer. Preclinical models of localized primary tumors and me

15703 records 280/1047 page Previous Next First page 上5页 276277278279280 下5页 Last page