• Una de las grandes consecuencias de la II

  2018-10-25

  

  Una de las grandes consecuencias de la II Guerra Mundial fue la ulterior Declaración Universal de Derechos Humanos, desarrollada y escrita por profesores, abogados y políticos, muchos de ellos latinoamericanos. Esta acción ha inspirado una agenda global de derechos humanos y ha creado una plataforma

• br Material and methods br

  2018-10-24

  

  Material and methods Acknowledgement We thank Jane Hagelskjær Knudsen, Christian Knudsen, and Bettina Hansen for excellent technical assistance. This project was supported by Aarhus University and partially by the Lundbeck Foundation (R151-2013-14439) and Danish Council for Independent Researc

• Previously we succeeded in visualizing the DNA

  2018-10-24

  

  Previously, we succeeded in visualizing the DNA methylation status by injecting a GFP-fused MBD of MBD1 protein (EGFP-MBD-NLS) mRNA into living mice zygotes. Using this method, we visualized the DNA methylation dynamics in preimplantation mouse embryos and found that DNA hypomethylation of major and

• br Experimental Procedures br Acknowledgments

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction New neurons are continuously generated in the hippocampal dentate gyrus (DG) throughout life in mammals, including rodents (Altman and Das, 1965; Kaplan and Hinds, 1977; Kuhn et al., 1996), nonhuman primates (Gould et al., 1999; Kornack a

• One of these factors SWI SNF

  2018-10-24

  

  One of these factors, SWI/SNF, is a large chromatin-remodeling complex that contains either BRG1 or BRM exclusively as the catalytic ATPase subunit that drives the alteration of DNA-nucleosome structure and thus regulates gene transcription (Fryer and Archer, 1998; Trotter and Archer, 2008; Wang et 

• There are three possible explanations for our

  2018-10-24

  

  There are three possible explanations for our findings. First, it is possible that the reprogramming process resulted in iPSCs that were solely derived from methylated FM fibroblasts and not of the unmethylated cells. This assumes that methylated FM fibroblasts were present in our culture, which acc

• iPSC derived iHLCs offer a

  2018-10-24

  

  iPSC-derived iHLCs offer a unique advantage in that they can be generated from any donor, which allows a broad spectrum of the human population to be represented in in vitro drug screens and provides an opportunity to assess donor-specific drug responses in vitro. Recent collaborations between drug

• iPSC derived iHLCs offer a

  2018-10-24

  

  iPSC-derived iHLCs offer a unique advantage in that they can be generated from any donor, which allows a broad spectrum of the human population to be represented in in vitro drug screens and provides an opportunity to assess donor-specific drug responses in vitro. Recent collaborations between drug

• Here we present an algorithm KeyGenes

  2018-10-24

  

  Here we present an algorithm, KeyGenes, that we have used on NGS data extracted from tissues of 21 different human fetal organs, both embryonic and extraembryonic (plus the maternal endometrium), from the first and second trimesters of development to determine a panel of classifier genes that would

• EZ Cap Reagent GG br Introduction Cardiac and skeletal myoge

  2018-10-24

  

  Introduction Cardiac and skeletal myogenesis both generate striated muscle, but are traditionally thought of as two separate processes with distinct developmental anlagen. However, recent work suggests the existence of at least one bipotent anlage for cardiac and skeletal muscle: the common proge

• Several strategies have been recently developed for

  2018-10-24

  

  Several strategies have been recently developed for CBC cell isolation via cell surface markers and fluorescence-activated cell sorting (FACS; Gracz et al., 2013; King et al., 2012; Merlos-Suarez et al., 2011; Wang et al., 2013). Although they represent considerable advances in the isolation of CBC

• The role of Wnt catenin signaling

  2018-10-24

  

  The role of Wnt/β-catenin signaling in reprogramming has also been investigated. Exogenously introduced WNT3A enhances fibroblast reprogramming in the absence of c-Myc (Marson et al., 2008). Knockdown or knockout of T cell factors or treatments with several drugs that control the Wnt pathway can cha

• CD also known as CUB domain containing

  2018-10-24

  

  CD318, also known as CUB domain-containing protein 1, acts as a substrate for Src family kinases and is associated with the metastatic potential of cancer prostaglandin receptor (Wortmann et al., 2009). In addition to cancer cells, CD318 has been reported to be present in several stem/progenitor pop

• Due to specific and well characterized genetic tools such as

  2018-10-24

  

  Due to specific and well-characterized genetic tools such as Villin-Cre mice, which allow for epithelium-specific transgene expression or Cre-mediated genetic excision of conditional urokinase in the intestine, many studies have focused on late development (Madison et al., 2002; El Marjou et al., 2

• The expression of RET tyrosine kinase receptor in

  2018-10-24

  

  The expression of RET tyrosine kinase receptor in UB tip cells is regulated by multiple signaling pathways. For example, WNT-β-catenin activity that first appears in UB and then persists in UB tip cells during kidney development was shown to be required for maintaining UB tip identity from studies u

15676 records 1041/1046 page Previous Next First page 上5页 10411042104310441045 下5页 Last page