• br Introduction This article deals with the relation between

  2018-10-30

  

  Introduction This article deals with the relation between innovation and employment at the firm level. Our focus is on formalized and structured innovation, i.e. new products and/or processes generated by an initial R&D expenditure. As explained by Dosi (1988) and Pavitt (1984), innovation strate

• Second there are several studies that aimed to estimate

  2018-10-30

  

  Second, there are several studies that aimed to estimate the causal impact of the conditional cash transfer programs on adult labor supply in Brazil (e.g., Soares et al., 2007; Ferro and Nicollela, 2007; Tavares, 2008; Teixeira, 2008; Covre et al., 2008; Foguel and de Barros, 2008). These studies us

• p53 tumor suppressor It is also worth noting that the curren

  2018-10-30

  

  It is also worth noting that the current relevance of cardinality-constrained portfolios is controversial. The main reason is straightforward: with the advent of new financial instruments such as exchange traded funds (ETF), nowadays investors can easily buy or sell a benchmark portfolio by investin

• gsk3b inhibitor In this paper after this introduction we dea

  2018-10-30

  

  In this paper, after this introduction, we deal with the oversight just mentioned. An alternative treatment is given to the existence of a proper solution involving a Hypercube Graph, which we call, by analogy with the magic square, the magic hypercube. In order for this paper to be self-contained,

• br Introduction Hepatitis C virus HCV infection has a

  2018-10-30

  

  Introduction Hepatitis C virus (HCV) infection has a high prevalence, incidence, and pathogenicity, and may evolve into cirrhosis and hepatocellular carcinoma (HCC) (Castello et al., 2010). HCV infection is considered a chronic liver disease, likely resulting from immune evasion by HCV quasi-spec

• In this issue of Ezzikouri et al reported on the

  2018-10-30

  

  In this issue of , Ezzikouri et al. reported on the use of a novel serum marker, 3β-hydroxysterol Δ24-reductase auto-antibody (DHCR24 Ab), as a surrogate marker to indicate progression from chronic hepatitis C to HCC (). By evaluating serum levels of the antibody in patients with different stages of

• From the therapeutic viewpoint the

  2018-10-30

  

  From the therapeutic viewpoint, the best and quick way to address the hurdles of controlling parasitic nematodes lies in the solid understanding of the basic biology of the organism and drawing parallels to targets of approved drugs that already have established safety profiles. This approach of rep

• br Introduction The Middle East respiratory syndrome coronav

  2018-10-30

  

  Introduction The Middle East respiratory syndrome coronavirus (MERS-CoV) is the only lineage C betacoronavirus known to infect humans (Annan et al., 2013; Anthony et al., 2013; van Boheemen et al., 2012). Similarly to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV infection ca

• mth1 inhibitor Indeed we observed some important modificatio

  2018-10-30

  

  Indeed, we observed some important modifications in the activation of APC from CS-exposed mice, but also in not conventional lymphocytes. Major cellular sources of IL-17 and IL-22, described as NK, NKT, ILC in mice and humans (Colonna, 2009; Liang et al., 2006; Sonnenberg et al., 2012; Van Maele et

• Transcription of integrated HIV is

  2018-10-30

  

  Transcription of integrated HIV-1 is stochastic, and reversal of the latent state using a single agent can be limited by specific factors, including restrictions posed by the site of integration of the virus and its molecular environment, subtypes of the latent virus and their susceptibility to a si

• Considering the role of the environment and gut microbiome

  2018-10-30

  

  Considering the role of the environment and gut microbiome in the pathobiology of the disease (Li and Jia, 2013; Wilson, 2009), a “pharmacometabolomics-aided pharmacogenomics” strategy could be of great benefit, as pharmacogenomics alone fails to address environmental influences. Taking into account

• From a clinical standpoint it is important to differentiate

  2018-10-30

  

  From a clinical standpoint, it is important to differentiate migraine-induced stroke (i.e., a rare and distinct occurrence of stroke following typical attack of migraine with aura, also known as “migrainous infarction”), from migraine-related stroke. In fact, the latter occurs remotely from a migrai

• The findings of this meta

  2018-10-30

  

  The findings of this buy GSK256066 meta-analysis should be interpreted with caution because of several limitations. First, we excluded conference abstracts, reviews, editorials, case reports and articles not written in English or Chinese, which may bias our results. In addition, we omitted unpublis

• Different formats have been developed for

  2018-10-30

  

  Different formats have been developed for detection of resistance conferring mutations in MTB. Compared to the GeneXpert MTB/RIF assay (Boehme et al., 2010) which is limited to the detection of rifampicin resistance, line probe assays are particularly attractive due to their unmatched versatility, i

• Molecular features of STING have been investigated by

  2018-10-30

  

  Molecular features of STING have been investigated by many research groups, and a number of amino AP24534 residues implicated for STING function have been identified. Those residues include phosphosites to induce the activation of the IFN-β promoter (Konno et al., 2013; Tanaka and Chen, 2012; Zhong

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